I wondered why i have never seen anyone making music with a siren so i had to try it myself.
It was started when i browsed thingiverse and found a nice little siren model and i had all the parts i needed around.
The interface is based on an arduino micro as a midi interface to generate a ppm signal to use with hobby escs based on incoming notes.
If the esc and motor respond quickly enough and hold the speed well it can be used as a (probably terrible) instrument.
I was pretty surprised how well it actually workded and expected it to be much worse.
The speed is not really regulated other than by the calibrated esc and a fixed voltage source and the spin up and down time depends on the inertia of the rotor and how good the esc can brake.
Fast quadcopter escs and a strong motor are preferred for this.
Some escs offer closed loop speed controlling which would be even better.
I have used a cheap racerstar lite 20A esc running blheli and a spare 2204 multistar elite 2300kv motor.